College Football Picks: Week 6 Predictions For Every Game

The Saturday slate for Week 6 is underway with the Red River Showdown kicking off the day's big games. But no matter what time you choose to tune in to today's slate of college football action, you should easily be able to find contest of massive interest considering there are three contests featuring top 25 opponents scattered throughout the day. In other words, with conference play having begun, there is plenty to feast on and upsets are bound to get started this week. Every lower-ranked team has an opportunity to knock a top 10 team off as most of the spreads in these games stand at a touchdown or less.

With action beginning early in the day and continuing late into the evening, let's take a look at the biggest games on the schedule Saturday along with our predictions for what will transpire in those contests. Our CBS Sports college football experts have picked every game both straight up and against the spread, giving you ample opportunity to decide how to make your picks ahead of kickoff.

All times Eastern

No. 19 Texas vs. No. 7 Oklahoma (-7.5) -- Noon on FOX: The Longhorns have a good recent history of covering in this game. Their defense has been stout enough lately to keep this one within range. Both teams have cut it close in a couple of games already, so don't be shocked if that's the case again here (or if the under hits). It's going to be hard to contain everything Oklahoma can throw at it, but Texas has enough answers to take the points. 

Pick: Texas +7.5 -- Ben Kercheval

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No. 5 LSU at No. 22 Florida (+2.5) -- 3:30 p.m. on CBS: Defense will lead the way Saturday afternoon, which makes the pick for this game rather simple. Which quarterback do you trust more, Joe Burrow on the road or Feleipe Franks at home. The game will likely be low scoring, which means one or two throws could make a world of difference. We saw Burrow do exactly that, when he made two clutch throws on third-and-7 and fourth-and-7 to move the chains on the game-winning drive vs. Auburn. That's enough to earn my trust, and pick the Tigers to prevail. 

Pick: LSU (-2.5) -- Barrett Sallee