Could A Blood Test Spot Early Stage Colon Cancer?

THURSDAY, Jan. 18, 2018 (HealthDay News) -- A simple, cheap blood test to detect colon cancer -- even in its early stages -- appears highly effective and accurate, new research indicates.

The test detects so-called "circulating tumor cells" (CTCs). Researchers tested it on 620 people in Taiwan who were scheduled for a routine colonoscopy at a local hospital.

By comparing the blood test results with the colonoscopy results, the study team found that the blood test identified colon cancer in 87 percent of cases, ranging from stage I to stage IV cancer. The blood test also was able to detect 77 percent of pre-cancerous lesions indicating early stage disease.

The researchers described the test as highly accurate, noting that it correctly identified cancer 84 to 88 percent of the time. Less than 3 percent of the time did it produce a "false positive" result, which mistakenly indicates the presence of cancer when there is none.

"Because the test can easily be made available for under $150, it could potentially be offered directly to consumers and ordered by physicians, with colonoscopy being the confirmatory diagnostic," said study author Dr. Ashish Nimgaonkar.

The test is not yet available in the United States. If and when it does come to market, he said, it probably would not replace colonoscopy as the gold standard for screening. Rather, it most likely would supplant the preliminary stool-based tests that people often are reluctant to use, Nimgaonkar said.

"This test could be an option for such individuals, boosting compliance" because it has a "higher sensitivity" than the stool-based screening options now available, he said.

Nimgaonkar is a gastroenterologist and medical director of Johns Hopkins University's Center for Bioengineering Innovation and Design, in Baltimore. He and his colleagues are scheduled to present their findings Jan. 20 in San Francisco at the American Society of Clinical Oncology's Gastrointestinal Cancers Symposium.

Experts note that research presented at meetings should be considered preliminary because it has not been subjected to the rigorous scrutiny given to research published in medical journals.

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