The mystery of what happened to the Princes in the Tower is one of the most enduring in English history.
Richard III's brother Edward IV, died unexpectedly in 1483.
Richard was made Lord Protector with charge of his two nephews: The young Edward V, aged 12, and his nine-year old brother, Richard, Duke of York.
The boys were locked up in the Tower of London and never seen again.
The suggestion is that Richard had had both boys murdered, just in case anyone tried to dispute his rights and sought to put young Edward back on the throne.
In 1674, almost 200 years after their death, the two skeletons were discovered under the stairs in the tower and reburied in Westminster Abbey.
The skeletons in the Abbey were last examined in 1933, but scientists were then unable to determine their sex, let alone find any clues to their identities.
Source : http://www.dailymail.co.uk/sciencetech/fb-5945871/WHO-PRINCES-TOWER.html158